Peptides are everywhere in skincare now, but the truth is most formulas treat them like glitter the more the better. That approach sounds impressive on paper, but skin doesn’t work that way. Peptides are signals. They need clarity, compatibility, and real structure behind them to do anything meaningful.
At DERMA-CODE™, we build peptide systems with intention, not volume. Both of our formulations use a six-peptide matrix, but the two matrices are not the same. Each product carries its own curated network designed around the biology of where it sits in the routine one for precision resurfacing support, one for barrier-first recovery.
This is the science behind how those peptides actually work.
Why Peptides Matter: Real Cell Signaling
Peptides are short chains of amino acids that act like messengers. They tell the skin what to do firm here, soothe here, rebuild here, relax tension here. But that communication only works when:
- The peptides are stable in the formula
- They exist in meaningful concentrations
- They are not sending overlapping or conflicting signals
Too many peptides can overwhelm the system. Too few do almost nothing. The sweet spot is strategy.
That’s why our six-peptide matrices were built the way they were: each peptide has a defined job, and no two peptides compete for the same receptor pathway.
The DERMA-CODE™ NAD+ • PDRN • 6 Peptide SERUM:
Six peptides chosen for precision, structure, and visible refinement
The serum is the “signal first” step. It targets the deeper communication pathways that influence smoothness, expression lines, and structural support.
Peptides in the Serum:
1. Acetyl Hexapeptide-8
Supports softer expression lines by easing repetitive micro-tension.
2. Acetyl Octapeptide-3
Complements Hexapeptide-8 to help refine surface smoothness.
3. Palmitoyl Tripeptide-1
Signals fibroblasts to support collagen renewal.
4. Palmitoyl Tetrapeptide-7
Helps calm visible stress and supports the skin’s regenerative environment.
5. Palmitoyl Pentapeptide-4
Targets structural protein networks for increased firmness and resilience.
6. Copper Tripeptide-1
Supports elasticity and visible recovery while helping skin maintain a balanced repair cycle.
Why these six together:
They support expression relaxation, collagen communication, and restorative balance without harsh resurfacing. The serum’s actives (PDRN + NAD⁺) give cells the environment to respond, and the peptides tell the skin how to perform within that environment.
The DERMA-CODE™ NAD+ • PDRN • 6 Peptides Facial Moisturizer:
Six peptides chosen for comfort, reinforcement, and barrier stability
The moisturizer was built to be a finishing step the layer that protects, comforts, and extends the performance of the serum.
Peptides in the Moisturizer:
1. Palmitoyl Tripeptide-1
Supports collagen communication and firmness.
2. Palmitoyl Tripeptide-8
Known for its calming properties, ideal for barrier-first recovery.
3. Acetyl Heptapeptide-4
Helps resist visible glycation effects and supports overall resilience.
4. Heptapeptide-6
Targets structural signaling and long-term firmness.
5. Oligopeptide-1 (EGF-type peptide)
Supports healthy surface renewal and smoothness without exfoliation.
6. Acetyl Hexapeptide-8
Adds a smoothing component that complements the serum when layered.
Why these six together:
They reinforce the skin’s comfort, balance, and structure while the moisturizer’s barrier-supportive base (ceramides, cholesterol, squalane) helps create the ideal environment for long-term peptide performance.
Why Six is the Sweet Spot
Across peer-reviewed research, peptides work best when:
• They are used in compatible groups
• Each peptide has a defined non-overlapping role
• The lipid/water environment is controlled
• Concentrations meet functional thresholds
More peptides do not equal better results they simply divide the formula into doses too small to matter. We avoided that trap completely.
Our six-peptide matrices were engineered around:
• Signaling clarity
• Stability
• Biological relevance
• Real-world skin compatibility
• Long-term use without irritation
This is why our peptides feel refined rather than aggressive. They’re not shouting over each other; they’re working in sequence.
The Synergy That Makes This Work
Peptides alone aren’t enough. They need energy, repair, and stability behind them.
That’s where our Tri-Active System comes in.
NAD⁺ supplies cellular energy.
PDRN supports regenerative signaling.
Peptides instruct structure and surface behavior.
Together, they create a more organized environment for visible improvement one based on biology, not marketing hooks.
Final Thought
Peptides can transform skin, but only when they’re used with intention. At DERMA-CODE™, our peptide matrices were built to communicate clearly, perform consistently, and work in synergy with the skin’s natural biology.
This is what happens when precision comes before hype.
We earn trust through results, not promises.
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