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DERMA-CODE™ Science

The Science Behind Transparency: Why Ingredient Labels Do Not Always Tell the Whole Story
A honest look at why skincare labels often sound impressive but tell you very little. This article breaks down the difference between real formulation integrity and “label dressing,” and explains why DERMA-CODE commits to true ingredient transparency and meaningful concentrations. Read more...
What Is the Tri-Active System? The Science Behind DERMA-CODE™’s Molecular Stability Framework
A clear explanation of DERMA-CODE’s proprietary Tri-Active System and how it stabilizes NAD⁺, PDRN, and peptides inside one controlled network. This article walks through why stability matters more than ingredient count, and how this system keeps each molecule functional and balanced. Read more...
PDRN vs Retinol: The Science Behind a New Era of Skin Renewal
A side-by-side comparison of PDRN and retinol that helps readers understand why irritation-based renewal isn’t the only option anymore. This article explains how PDRN supports the skin’s own repair signals while avoiding the dryness and sensitivity retinol often causes. Read more...
NAD⁺ vs Niacinamide: From Surface Support to Cellular Repair
Niacinamide is valuable, but NAD⁺ is the coenzyme the skin actually uses. This breakdown shows how the two molecules relate, why conversion slows with age, and how stabilized NAD⁺ can directly support energy, repair, and visible vitality in a way niacinamide alone cannot. Read more...
The Science of Synergy: How NAD⁺, PDRN, and Peptides Work Together
A deeper look at how DERMA-CODE’s three core actives interact rather than compete. This article shows how energy (NAD⁺), regeneration (PDRN), and targeted communication (peptides) work in sequence to support smoother, more resilient skin. Read more...
The Power of Six: How Our Advanced Peptide Matrix Supports Visible Skin Architecture
A breakdown of the six-peptide strategies in both DERMA-CODE formulas, explaining what each peptide does and why they were selected. Instead of overwhelming blends, this matrix focuses on clear communication, structural support, and visible smoothness. Read more...
PDRN Molecular Weight: Why 50–300 kDa Matters for Skin Renewal
This article explains why molecular weight determines how PDRN behaves on the skin, and why DERMA-CODE uses a controlled 50–300 kDa range. It also details how our biomimetic surface-delivery environment supports PDRN’s stability and visible results. Read more...
Polynucleotides and PDRN in Aesthetic Medicine: What Current Research Really Shows
A research-focused summary of the most important findings from current literature on polynucleotides and PDRN. This article reviews what clinicians are seeing in real-world practice, highlights safety outcomes, and includes the full NIH-indexed review for transparency. Read more...