Why these three ingredients needed each other
Most people hear about skincare ingredients one by one. NAD⁺ for energy. PDRN for regeneration. Peptides for structure. In reality, they only show their full strength when they’re supported by the right environment and by each other.
DERMA-CODE™ was built on that idea. Instead of treating ingredients like isolated features, we look at how they behave together, how they communicate, and how the formula surrounding them protects their integrity.
This is the foundation of our synergy system.
1. NAD⁺ - Energy That Keeps Skin Performing
NAD⁺ (Nicotinamide Adenine Dinucleotide) is one of the most important coenzymes in the body. It fuels DNA repair, cellular energy, and the pathways linked to healthy aging. As NAD⁺ levels decline over time, the skin becomes slower to recover from stress, environmental damage, and everyday wear.
Research continues to show that replenishing NAD⁺ helps cells function more efficiently, especially when the ingredient is delivered in a protected, stabilized form. That protection is crucial, because NAD⁺ is extremely sensitive to heat, light, and oxidation.
How we support it in formulation:
Our serum uses humectants and lightweight emollients so NAD⁺ can spread evenly across the skin. The moisturizer adds ceramides, cholesterol, and squalane to create a breathable layer that keeps NAD⁺ in contact with the surface long enough to be useful.
The result is energy support that feels gentle but steady, never aggressive.
2. PDRN - Regeneration Through Molecular Signaling
PDRN (Polydeoxyribonucleotide) is a purified DNA fragment complex known for helping the skin maintain comfort, hydration, and visible renewal. It communicates through adenosine A2A receptors, which play a major role in collagen signaling and overall tissue repair.
Not all PDRN works the same way. Molecular size determines how well it interacts with the skin.
Our approach:
We use a 50–300 kDa range, chosen for topical bioavailability. It’s small enough to communicate at the surface, but large enough to retain the signaling integrity that makes PDRN valuable.
To keep PDRN comfortable and active, we surround it with ingredients like panthenol and allantoin an environment that mimics the supportive conditions the molecule prefers.
3. Peptides - Precise Communication, Not Overcrowded Noise
Peptides are short strands of amino acids that act like messengers. They tell cells when to firm, smooth, repair, or calm. But peptides only work if their signals are clear. Too many unrelated peptides can cancel each other out.
That’s why DERMA-CODE™ uses a targeted peptide matrix rather than an oversized list.
In the NAD+ • PDRN • 6 Peptide SERUM:
• Acetyl Hexapeptide-8
• Acetyl Octapeptide-3
• Palmitoyl Tripeptide-1
• Palmitoyl Tetrapeptide-7
• Palmitoyl Pentapeptide-4
• Copper Tripeptide-1
Each was selected for a distinct purpose: expression lines, structural support, resilience, or visible smoothness.
In the NAD+ • PDRN • 6 Peptides Facial Moisturizer:
• Palmitoyl Tripeptide-1
• Palmitoyl Tripeptide-8
• Acetyl Heptapeptide-4
• Heptapeptide-6
• Oligopeptide-1
• Acetyl Hexapeptide-8
Together, they cover firmness, barrier comfort, and surface renewal without overlapping or competing.
4. How Synergy Creates Real Performance
When NAD⁺, PDRN, and peptides share a stable environment, they reinforce each other’s strengths:
• NAD⁺ supports the energy processes that help cells repair.
• PDRN provides the signaling that encourages balanced regeneration.
• Peptides give structural direction and visible firmness.
Layering the serum and moisturizer amplifies this effect. The serum delivers the full activity of NAD⁺, PDRN, and peptides directly onto the skin. The moisturizer acts like a breathable shield, extending contact time and supporting barrier function so the system can work without interruption.
This is the quiet science behind skin that looks steady, strong, and balanced not just temporarily improved.
The Bottom Line
Synergy is not a buzzword here. It’s the core of how DERMA-CODE™ formulates.
NAD⁺, PDRN, and peptides don’t just coexist they depend on one another.
When the environment is correct, you get renewal that feels calm.
Repair that feels natural.
Structure that feels like your own skin just better supported.
We earn trust through results, not promises.
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